Experimental antileukocyte interventions in cerebral ischemia.

Publication Type	Review
Authors	Härtl R, Schürer L, Schmid-Schönbein G, del Zoppo G
Journal	J Cereb Blood Flow Metab
Volume	16
Issue	6
Pagination	1108-19
Date Published	11/01/1996
ISSN	0271-678X
Keywords	Brain Ischemia, Leukocytes
Abstract	White blood cells (WBCs) play vital roles in host defense. Recently, increasing interest has been directed toward the question of whether WBCs, particularly polymorphonuclear leukocytes, could also act as mediators of secondary brain damage in the setting of focal and global cerebral ischemia with and without reperfusion. Considerable insight into the importance of WBC-mediated tissue injury has been gained from studies employing antileukocyte interventions in experimental cerebral ischemia. The purpose of this article is to survey the different approaches taken to interfere with WBC inflammatory function. Emphasis is laid on a discussion of the efficacy of these interventions, their effects and side effects on cerebral and systemic parameters, and the power of evidence they provide for identification of WBCs as important factors in cerebral ischemia. The role of WBCs has been investigated in a great variety of global and focal cerebral ischemia models with and without reperfusion, leading to sometimes contradictory results. In the light of currently available data, it seems likely that WBCs contribute to secondary brain damage in the scenario of experimental transient focal cerebral ischemia, if the insult is not too severe.
DOI	10.1097/00004647-199611000-00004
PubMed ID	8898682