Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain.
| Publication Type | Academic Article |
| Authors | Ivanidze J, Mackay M, Hoang A, Chi J, Cheng K, Aranow C, Volpe B, Diamond B, Sanelli P |
| Journal | AJNR Am J Neuroradiol |
| Volume | 40 |
| Issue | 3 |
| Pagination | 408-411 |
| Date Published | 02/07/2019 |
| ISSN | 1936-959X |
| Keywords | Blood-Brain Barrier, Hippocampus, Magnetic Resonance Imaging, Neuroimaging |
| Abstract | We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role. |
| DOI | 10.3174/ajnr.A5962 |
| PubMed ID | 30733256 |
| PubMed Central ID | PMC7028673 |