Time-dependent diffusivity and kurtosis in phantoms and patients with head and neck cancer.

Publication Type	Academic Article
Authors	Solomon E, Lemberskiy G, Baete S, Hu K, Malyarenko D, Swanson S, Shukla-Dave A, Russek S, Zan E, Kim S
Journal	Magn Reson Med
Volume	89
Issue	2
Pagination	522-535
Date Published	10/11/2022
ISSN	1522-2594
Keywords	Diffusion Magnetic Resonance Imaging, Head and Neck Neoplasms
Abstract	PURPOSE: To assess the reliability of measuring diffusivity, diffusional kurtosis, and cellular-interstitial water exchange time with long diffusion times (100-800 ms) using stimulated-echo DWI. METHODS: D RESULTS: D CONCLUSIONS: Based on two well-established diffusion phantoms, we found that time-dependent diffusion MRI measurements can provide stable diffusion and kurtosis values over a wide range of diffusion times and across multiple MRI systems. Moreover, estimation of cellular-interstitial water exchange time can be achieved using the Kärger model for the metastatic lymph nodes in patients with head and neck cancer.
DOI	10.1002/mrm.29457
PubMed ID	36219464
PubMed Central ID	PMC9712275