Time-dependent diffusivity and kurtosis in phantoms and patients with head and neck cancer.
| Publication Type | Academic Article |
| Authors | Solomon E, Lemberskiy G, Baete S, Hu K, Malyarenko D, Swanson S, Shukla-Dave A, Russek S, Zan E, Kim S |
| Journal | Magn Reson Med |
| Volume | 89 |
| Issue | 2 |
| Pagination | 522-535 |
| Date Published | 10/11/2022 |
| ISSN | 1522-2594 |
| Keywords | Diffusion Magnetic Resonance Imaging, Head and Neck Neoplasms |
| Abstract | PURPOSE: To assess the reliability of measuring diffusivity, diffusional kurtosis, and cellular-interstitial water exchange time with long diffusion times (100-800 ms) using stimulated-echo DWI. METHODS: D RESULTS: D CONCLUSIONS: Based on two well-established diffusion phantoms, we found that time-dependent diffusion MRI measurements can provide stable diffusion and kurtosis values over a wide range of diffusion times and across multiple MRI systems. Moreover, estimation of cellular-interstitial water exchange time can be achieved using the Kärger model for the metastatic lymph nodes in patients with head and neck cancer. |
| DOI | 10.1002/mrm.29457 |
| PubMed ID | 36219464 |
| PubMed Central ID | PMC9712275 |