Assessment of Background Parenchymal Enhancement and Lesion Kinetics in Breast MRI of BRCA 1/2 Mutation Carriers Compared to Matched Controls Using Quantitative Kinetic Analysis.

Publication Type	Academic Article
Authors	Lewin A, Kim S, Babb J, Melsaether A, McKellop J, Moccaldi M, Klautau Leite A, Moy L
Journal	Acad Radiol
Volume	23
Issue	3
Pagination	358-67
Date Published	01/07/2016
ISSN	1878-4046
Keywords	BRCA1 Protein, BRCA2 Protein, Breast, Breast Neoplasms, Heterozygote, Image Enhancement, Magnetic Resonance Imaging, Mutation
Abstract	RATIONALE AND OBJECTIVES: To investigate whether quantitative kinetic analysis of lesions and background parenchyma in breast magnetic resonance imaging can elucidate differences between BRCA carriers and sporadic controls with high risk for breast cancer. MATERIALS AND METHODS: Fifty-nine BRCA and 59 control cases (49 benign, 10 malignant) were examined in this study. Principal component analysis was applied for quantitative analysis of dynamic signal in background parenchyma (B) and lesion (L) in terms of initial enhancement ratio (IER) and delayed enhancement ratio (DER). RESULTS: Control B-IER, B-DER, L-IER, and L-DER were higher than BRCA cases in all women and in women with benign lesions; statistically significant differences in B-IER and B-DER (all women: P = 0.02 and P = 0.02, respectively; benign only: P = 0.005 and P = 0.005, respectively). In the control cohort, B-IER and B-DER were higher in the premenopausal women than in the postmenopausal women (P = 0.013 and 0.003, respectively), but not in the BRCA cohort; this led to significant differences in B-IER and B-DER between the control and the BRCA groups in the premenopausal women (P = 0.01 and 0.01, respectively) but not in the postmenopausal women. CONCLUSION: Results suggest possible differences in the vascular properties of background parenchyma between BRCA carriers and noncarriers and its association with menopausal status.
DOI	10.1016/j.acra.2015.11.011
PubMed ID	26774741
PubMed Central ID	PMC5893133