Magnetic resonance imaging (MRI) of hormone-induced breast changes in young premenopausal women.

Publication Type	Academic Article
Authors	Clendenen T, Kim S, Moy L, Wan L, Rusinek H, Stanczyk F, Pike M, Zeleniuch-Jacquotte A
Journal	Magn Reson Imaging
Volume	31
Issue	1
Pagination	1-9
Date Published	08/13/2012
ISSN	1873-5894
Keywords	Breast, Contraceptives, Oral, Hormonal, Magnetic Resonance Imaging, Menstrual Cycle
Abstract	OBJECTIVES: We conducted a pilot study to identify whether MRI parameters are sensitive to hormone-induced changes in the breast during the natural menstrual cycle and whether changes could also be observed during an oral contraceptive (OC) cycle. MATERIALS AND METHODS: The New York University Langone Medical Center Institutional Review Board approved this HIPAA-compliant prospective study. All participants provided written informed consent. Participants were aged 24-31 years.We measured several non-contrast breast MRI parameters during each week of a single menstrual cycle (among 9 women) and OC cycle (among 8 women). Hormones were measured to confirm ovulation and classify menstrual cycle phase among naturally cycling women and to monitor OC compliance among OC users. We investigated how the non-contrast MRI parameters of breast fibroglandular tissue (FGT), apparent diffusion coefficient (ADC), magnetization transfer ratio (MTR), and transverse relaxation time (T2) varied over the natural and the OC cycles. RESULTS: We observed significant increases in MRI FGT% and ADC in FGT, and longer T2 in FGT in the luteal vs. follicular phase of the menstrual cycle. We did not observe any consistent pattern of change for any of the MRI parameters among women using OCs. CONCLUSIONS: MRI is sensitive to hormone-induced breast tissue changes during the menstrual cycle. Larger studies are needed to assess whether MRI is also sensitive to the effects of exogenous hormones, such as various OC formulations, on the breast tissue of young premenopausal women.
DOI	10.1016/j.mri.2012.06.022
PubMed ID	22898693