A multicenter study of two magnetic resonance spectroscopy techniques in individuals with HIV dementia.
| Publication Type | Academic Article |
| Authors | Sacktor N, Skolasky R, Ernst T, Mao X, Selnes O, Pomper M, Chang L, Zhong K, Shungu D, Marder K, Shibata D, Schifitto G, Bobo L, Barker P |
| Journal | J Magn Reson Imaging |
| Volume | 21 |
| Issue | 4 |
| Pagination | 325-33 |
| Date Published | 04/01/2005 |
| ISSN | 1053-1807 |
| Keywords | AIDS Dementia Complex, Magnetic Resonance Spectroscopy |
| Abstract | PURPOSE: To evaluate single-voxel proton magnetic resonance spectroscopy (SV-MRS) and magnetic resonance spectroscopic imaging (MRSI) metabolite results in individuals with HIV dementia. MATERIALS AND METHODS: Twenty HIV-positive (HIV+) individuals underwent SV-MRS (TE 35 msec) and MRSI (TE 280 msec). Results were stratified according to serostatus, dementia severity, psychomotor speed performance, and functional impairment. RESULTS: HIV+ individuals with psychomotor slowing had an increased myoinositol/creatine (mI/Cr) ratio (0.63 vs. 0.45) in the frontal white matter using SV-MRS and an increased choline (Cho)/Cr ratio (1.88 vs. 1.41) in the mesial frontal gray matter using MRSI compared to HIV+ individuals without psychomotor slowing. Using MRSI, subjects with HIV dementia also had a decreased N-acetyl aspartate (NAA)/Cho ratio (1.55 vs. 2.53) compared to HIV+ individuals without cognitive impairment in the mesial frontal gray matter. Both techniques detected metabolite ratio abnormalities associated with abnormal functional performance. CONCLUSION: SV-MRS and MRSI offer complementary roles in evaluating individuals with HIV dementia. Short TE SV-MRS measures mI, which may be elevated in early HIV dementia, whereas MRSI provides wider spatial coverage to examine specific regional changes. |
| DOI | 10.1002/jmri.20272 |
| PubMed ID | 15779034 |