Semi-automatic segmentation of the placenta into fetal and maternal compartments using intravoxel incoherent motion MRI.

Publication Type	Academic Article
Authors	You W, Andescavage N, Zun Z, Limperopoulos C
Journal	Proc SPIE Int Soc Opt Eng
Volume	10137
Date Published	03/01/2017
ISSN	0277-786X
Abstract	Intravoxel incoherent motion (IVIM) magnetic resonance imaging is an emerging non-invasive technique that has been recently applied to quantify in vivo global placental perfusion. We propose a robust semi-automated method for segmenting the placenta into fetal and maternal compartments from IVIM data, using a multi-label image segmentation algorithm called 'GrowCut'. Placental IVIM data were acquired on a 1.5T scanner from 16 healthy pregnant women between 21-37 gestational weeks. The voxel-wise perfusion fraction was then estimated after non-rigid image registration. The seed regions of the fetal and maternal compartments were determined using structural T2-weighted reference images, and improved progressively through an iterative process of the GrowCut algorithm to accurately encompass fetal and maternal compartments. We demonstrated that the placental perfusion fraction decreased in both fetal (-0.010/week) and maternal compartments (-0.013/week) while their relative difference (f_fetal-f_maternal) gradually increased with advancing gestational age (+0.003/week, p=0.065). Our preliminary results show that the proposed method was effective in distinguishing placental compartments using IVIM.
DOI	10.1117/12.2254610
PubMed ID	28947842
PubMed Central ID	PMC5609721