Cognitive dysfunction in animal models of human lewy-body dementia.

Publication Type	Review
Authors	Haikal C, Winston G, Kaplitt M
Journal	Front Aging Neurosci
Volume	16
Pagination	1369733
Date Published	07/22/2024
ISSN	1663-4365
Abstract	Cognitive impairments are a common feature of synucleinopathies such as Parkinson's Disease Dementia and Dementia with Lewy Bodies. These pathologies are characterized by accumulation of Lewy bodies and Lewy neurites as well as neuronal cell death. Alpha-synuclein is the main proteinaceous component of Lewy bodies and Lewy neurites. To model these pathologies in vivo, toxins that selectively target certain neuronal populations or different means of inducing alpha-synuclein aggregation can be used. Alpha-synuclein accumulation can be induced by genetic manipulation, viral vector overexpression or the use of preformed fibrils of alpha-synuclein. In this review, we summarize the cognitive impairments associated with different models of synucleinopathies and relevance to observations in human diseases.
DOI	10.3389/fnagi.2024.1369733
PubMed ID	39104707
PubMed Central ID	PMC11298446