Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM).

Publication Type	Academic Article
Authors	Zhang Y, Gauthier S, Gupta A, Comunale J, Chia-Yi Chiang G, Zhou D, Chen W, Giambrone A, Zhu W, Wang Y
Journal	J Magn Reson Imaging
Volume	44
Issue	2
Pagination	426-32
Date Published	01/22/2016
ISSN	1522-2586
Keywords	Aging, Algorithms, Brain, Image Interpretation, Computer-Assisted, Multiple Sclerosis, Subtraction Technique
Abstract	PURPOSE: To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM). MATERIALS AND METHODS: The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced-with-Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow-up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t-test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change. RESULTS: Lesion susceptibility values relative to normal-appearing white matter (NAWM) changed from 3.61 ± 6.11 ppb when enhanced-with-Gd at the baseline MRI to 20.42 ± 10.23 ppb when not-enhanced-with-Gd at the follow-up MRI (P < 0.001). CONCLUSION: MS lesion susceptibility value increases significantly as the lesion evolves from enhanced-with-Gd to not-enhanced-with-Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426-432.
DOI	10.1002/jmri.25144
PubMed ID	26800367
PubMed Central ID	PMC4946979