Weill Cornell Medicine
Citigroup Biomedical Imaging Center
Weill Cornell Medicine
Citigroup Biomedical Imaging Center

Cerebrovascular reactivity to carbon dioxide in Alzheimer's disease.

Publication Type Review
Authors Glodzik L, Randall C, Rusinek H, de Leon M
Journal J Alzheimers Dis
Volume 35
Issue 3
Pagination 427-40
Date Published 01/01/2013
ISSN 1875-8908
Keywords Alzheimer Disease, Brain, Carbon Dioxide, Vasoconstriction
Abstract There is growing evidence that cerebrovascular reactivity to carbon dioxide (CVRCO2) is impaired in Alzheimer's disease (AD). Preclinical and animal studies suggest chronic hypercontractility in brain vessels in AD. We review (a) preclinical studies of mechanisms for impaired CVRCO2 in AD; (b) clinical studies of cerebrovascular function in subjects with AD dementia, mild cognitive impairment (MCI), and normal cognition. Although results of clinical studies are inconclusive, an increasing number of reports reveal an impairment of vascular reactivity to carbon dioxide in subjects with AD, and possibly also in MCI. Thus, CVRCO2 may be an attractive means to detect an early vascular dysfunction in subjects at risk.
DOI 10.3233/JAD-122011
PubMed ID 23478306
PubMed Central ID PMC3776495
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