Phosphorylated tau 231, memory decline and medial temporal atrophy in normal elders.

Publication Type	Academic Article
Authors	Glodzik L, de Santi S, Tsui W, Mosconi L, Zinkowski R, Pirraglia E, Wang H, Li Y, Rich K, Zetterberg H, Blennow K, Mehta P, de Leon M
Journal	Neurobiol Aging
Volume	32
Issue	12
Pagination	2131-41
Date Published	02/04/2010
ISSN	1558-1497
Keywords	Memory Disorders, Temporal Lobe, tau Proteins
Abstract	Little is known whether cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) can predict both memory decline and associated longitudinal medial temporal lobe (MTL) gray matter (GM) reductions in cognitively healthy individuals. Fifty-seven normal elderly subjects received comprehensive evaluation at baseline and 2 years later. The baseline phosphorylated tau(231) (p-tau(231)), total tau, the amyloid beta (Aβ) Aβ42/Aβ40, t-tau/Aβ42 and p-tau(231)/Aβ42 ratios were examined as predictors of memory change and reductions in the global and MTL GM, determined from T1-weighted MRI. Twenty out of 57 participants experienced reduced memory performance at follow-up. The group with decreased memory performance showed higher baseline p-tau(231) (Z=-2.2, p=0.03), lower Aβ42/Aβ40 (t=-2.2 [55], p=0.04) and greater longitudinal MTL GM reductions (t([52])=-2.70, p=0.01). Higher baseline p-tau(231) was also associated with the absolute decrease in memory scores (rho=-0.30, p=0.02) and with longitudinal MTL GM reduction (F([2,52])=4.4, p=0.04, age corrected). Our results indicate that in normal individuals, elevated p-tau(231), a marker of neurofibrillary pathology is related to both a decrease in declarative memory and progressive atrophy of the MTL, suggesting its diagnostic potential in preclinical stage.
DOI	10.1016/j.neurobiolaging.2009.12.026
PubMed ID	20133017
PubMed Central ID	PMC3179835