Synthesis of [1-11C]Butanol via a facile solid phase extraction protocol.
| Publication Type | Academic Article |
| Authors | Waterhouse N, Kothari P, Dooley M, Hu B, de Leon M, Babich J, Qu W |
| Journal | Appl Radiat Isot |
| Volume | 159 |
| Pagination | 109078 |
| Date Published | 02/08/2020 |
| ISSN | 1872-9800 |
| Abstract | A facile synthesis method for the preparation of [1-11C]butanol, a regional cerebral blood flow imaging agent, was developed. Using a solid phase extraction method, the highly polar and volatile molecule [1-11C]butanol was quickly concentrated, purified, and released as final product; boasting high radiochemical and chemical purities as well as high radiochemical yields. The final drug product was obtained as a sterile, pyrogen-free solution that conforms United States Pharmacopeia (USP) <823> requirements. |
| DOI | 10.1016/j.apradiso.2020.109078 |
| PubMed ID | 32068145 |