Periodontal disease as a possible cause for Alzheimer's disease.

Publication Type	Review
Authors	Kamer A, Craig R, Niederman R, Fortea J, de Leon M
Journal	Periodontol 2000
Volume	83
Issue	1
Pagination	242-271
Date Published	06/01/2020
ISSN	1600-0757
Keywords	Alzheimer Disease, Periodontal Diseases
Abstract	Approximately 47 million people worldwide have been diagnosed with dementia, 60%-80% of whom have dementia of the Alzheimer's disease type. Unfortunately, there is no cure in sight. Defining modifiable risk factors for Alzheimer's disease may have a significant impact on its prevalence. An increasing body of evidence suggests that chronic inflammation and microbial dysbiosis are risk factors for Alzheimer's disease. Periodontal disease is a chronic inflammatory disease that develops in response to response to microbial dysbiosis. Many studies have shown an association between periodontal disease and Alzheimer's disease. The intent of this paper was to review the existing literature and determine, using the Bradford Hill criteria, whether periodontal disease is causally related to Alzheimer's disease.
DOI	10.1111/prd.12327
PubMed ID	32385876