Cerebral oxygen extraction fraction declines with ventricular enlargement in patients with normal pressure hydrocephalus.
| Publication Type | Academic Article |
| Authors | Zhuang H, Cho J, Chiang G, Kovanlikaya I, Heier L, Dyke J, Wang Y |
| Journal | Clin Imaging |
| Volume | 97 |
| Pagination | 22-27 |
| Date Published | 02/10/2023 |
| ISSN | 1873-4499 |
| Keywords | Hydrocephalus, Normal Pressure, Neurodegenerative Diseases |
| Abstract | OBJECTIVE: Normal pressure hydrocephalus (NPH) is a neurodegenerative disease that is potentially reversible by shunt surgery in approximately 60% of patients. Imaging may provide a means to investigate brain tissue viability and oxygen metabolism in NPH patients. METHODS: Oxygen extraction fraction (OEF) mapping was generated from 3D multi-echo gradient echo MRI (mGRE) data using QQ-CCTV algorithm and cerebral blood flow (CBF) using 3D arterial spin labeling (ASL) MRI data, thereby calculating the cerebral metabolic rate of oxygen (CMRO2 = CBF × OEF × [H]a) in 16 NPH patients. Regression analyses using cortical gray matter and deep gray matter regions were conducted with age, gender, CSF stroke volume and normalized ventricular volume as independent variables. RESULTS: OEF showed significant negative correlations with normalized brain ventricular volumes in the whole brain (p = 0.004, q = 0.01), cortical gray matter (p = 0.004, q = 0.01), caudate (p = 0.02, q = 0.04), and pallidum (p = 0.03, q = 0.04), but no significant correlation with CSF stroke volume (q > 0.05). There was no significant finding with CBF or CMRO2. CONCLUSION: In NPH patients, low OEF in several regions was significantly correlated with large ventricular volumes, indicating decreased tissue oxygen metabolism with increased NPH severity. OEF mapping may provide a functional understanding of neurodegeneration in NPH and may improve monitoring of disease course and treatment outcomes. |
| DOI | 10.1016/j.clinimag.2023.02.001 |
| PubMed ID | 36871361 |
| PubMed Central ID | PMC10081162 |