Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease.

Publication Type	Academic Article
Authors	De Leon M, George A, Golomb J, Tarshish C, Convit A, Kluger A, De Santi S, McRae T, Ferris S, Reisberg B, Ince C, Rusinek H, Bobinski M, Quinn B, Miller D, Wisniewski H
Journal	Neurobiol Aging
Volume	18
Issue	1
Pagination	1-11
Date Published	01/01/1997
ISSN	0197-4580
Keywords	Aging, Alzheimer Disease, Hippocampus
Abstract	We used CT and MR to examine the frequency of occurrence of hippocampal formation atrophy (HA) in a research clinic population of 130 normal elderly, 72 nondemented patients with very mild memory and cognitive impairments (MCI), 73 mild Alzheimer's disease (AD) patients, and 130 patients with moderate to severe AD. HA was found in 29% of the normal elderly group and its frequency of occurrence was strongly related to increasing age. For normal elderly 60-75 years of age, 15% had HA: the proportion rose to 48% in subjects 76-90 years of age. Among the three groups of impaired patients, the frequencies of HA ranged from 78% in the MCI patients to 96% in the advanced AD group. Unlike the normal elderly group, the percentages were not related to age. In both the normal elderly group and MCI group disproportionately more males than females had HA. After controlling for learning and the effects of generalized brain changes as reflected in ventricular size, only in the normal group was HA associated with reduced delayed verbal recall performance. Follow-up examinations for 15 individuals with baseline HA. 4 who at entry were MCI and 11 probable AD, yielded clinical and neuropathologic diagnoses of AD in all cases. The results of the present study indicate that hippocampal formation atrophy is associated with memory and cognitive impairments. Further longitudinal and neuropathologic work is required to validate the relationship between hippocampal formation atrophy and AD.
DOI	10.1016/s0197-4580(96)00213-8
PubMed ID	8983027