Mild cognitive impairment.

Publication Type	Review
Authors	Gauthier S, Reisberg B, Zaudig M, Petersen R, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings J, de Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney M, Whitehouse P, Winblad B
Journal	Lancet
Volume	367
Issue	9518
Pagination	1262-70
Date Published	04/15/2006
ISSN	1474-547X
Keywords	Cognition Disorders, Dementia
Abstract	Mild cognitive impairment is a syndrome defined as cognitive decline greater than expected for an individual's age and education level but that does not interfere notably with activities of daily life. Prevalence in population-based epidemiological studies ranges from 3% to 19% in adults older than 65 years. Some people with mild cognitive impairment seem to remain stable or return to normal over time, but more than half progress to dementia within 5 years. Mild cognitive impairment can thus be regarded as a risk state for dementia, and its identification could lead to secondary prevention by controlling risk factors such as systolic hypertension. The amnestic subtype of mild cognitive impairment has a high risk of progression to Alzheimer's disease, and it could constitute a prodromal stage of this disorder. Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia.
DOI	10.1016/S0140-6736(06)68542-5
PubMed ID	16631882