Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's dise

Publication Type	Review
Authors	Kelly L, Brown C, Michalik D, Hawkes C, Aldea R, Agarwal N, Salib R, Alzetani A, Ethell D, Counts S, de Leon M, Fossati S, Koronyo-Hamaoui M, Piazza F, Rich S, Wolters F, Snyder H, Ismail O, Elahi F, Proulx S, Verma A, Wunderlich H, Haack M, Dodart J, Mazer N, Carare R
Journal	Alzheimers Dement
Volume	20
Issue	2
Pagination	1421-1435
Date Published	10/28/2023
ISSN	1552-5279
Keywords	Alzheimer Disease, Cerebral Amyloid Angiopathy, Cerebrovascular Disorders
Abstract	This editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age-related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid-related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA-related inflammation (CAA-ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy.
DOI	10.1002/alz.13512
PubMed ID	37897797
PubMed Central ID	PMC10917045