Weill Cornell Medicine
Citigroup Biomedical Imaging Center
Weill Cornell Medicine
Citigroup Biomedical Imaging Center

Elevated cerebellar glucose metabolism in microvascular white matter disease: normal aging and Alzheimer's disease.

Publication Type Academic Article
Authors Klinger A, de Leon M, George A, Miller J, Wolf A
Journal J Cereb Blood Flow Metab
Volume 8
Issue 3
Pagination 433-5
Date Published 06/01/1988
ISSN 0271-678X
Keywords Aging, Alzheimer Disease, Cerebellum, Glucose
Abstract Young normal, elderly, and clinically diagnosed Alzheimer disease subjects who had undergone positron emission tomography (PET) and computed tomography (CT) examinations were studied to determine the effect of periventricular white matter lesions on cerebellar glucose metabolic rates. PET-determined cerebellar metabolic rates were elevated in subjects with periventricular white matter lesions. These results suggest the cautious use of cortical-to-cerebellar ratios in future PET or single-photon-emission CT (SPECT) studies.
DOI 10.1038/jcbfm.1988.80
PubMed ID 3259243
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