Altered glucose metabolism in microvessels from patients with Alzheimer's disease.

Publication Type	Academic Article
Authors	Marcus D, de Leon M, Goldman J, Logan J, Christman D, Wolf A, Fowler J, Hunter K, Tsai J, Pearson J
Journal	Ann Neurol
Volume	26
Issue	1
Pagination	91-4
Date Published	07/01/1989
ISSN	0364-5134
Keywords	Alzheimer Disease, Blood Vessels, Deoxy Sugars, Deoxyglucose, Energy Metabolism, Hexokinase, Temporal Lobe
Abstract	Microvessels isolated from temporal cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age-matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.
DOI	10.1002/ana.410260114
PubMed ID	2774504