Weill Cornell Medicine
Citigroup Biomedical Imaging Center
Weill Cornell Medicine
Citigroup Biomedical Imaging Center

Duration of neurofibrillary changes in the hippocampal pyramidal neurons.

Publication Type Academic Article
Authors Bobinski M, Wegiel J, Tarnawski M, de Leon M, Reisberg B, Miller D, Wisniewski H
Journal Brain Res
Volume 799
Issue 1
Pagination 156-8
Date Published 07/13/1998
ISSN 0006-8993
Keywords Alzheimer Disease, Hippocampus, Neurofibrillary Tangles, Pyramidal Cells
Abstract The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyrus of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.
DOI 10.1016/s0006-8993(98)00441-7
PubMed ID 9666111
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