Duration of neurofibrillary changes in the hippocampal pyramidal neurons.

Publication Type	Academic Article
Authors	Bobinski M, Wegiel J, Tarnawski M, de Leon M, Reisberg B, Miller D, Wisniewski H
Journal	Brain Res
Volume	799
Issue	1
Pagination	156-8
Date Published	07/13/1998
ISSN	0006-8993
Keywords	Alzheimer Disease, Hippocampus, Neurofibrillary Tangles, Pyramidal Cells
Abstract	The total number of neurons with and without neurofibrillary changes in sectors CA1 to CA4, subiculum, and dentate gyrus of 16 subjects with Alzheimer disease (AD) was estimated. The duration of neurofibrillary changes was calculated on the basis of regressions between the duration of AD and neuronal numbers. In the CA1 and subiculum, it takes 3.4 and 5.4 years, respectively, for an intact neuron affected by neurofibrillary pathology to become a ghost tangle.
DOI	10.1016/s0006-8993(98)00441-7
PubMed ID	9666111