Positron emission tomographic studies of aging and Alzheimer disease.
| Publication Type | Academic Article |
| Authors | de Leon M, Ferris S, George A, Christman D, Fowler J, Gentes C, Reisberg B, Gee B, Emmerich M, Yonekura Y, Brodie J, Kricheff I, Wolf A |
| Journal | AJNR Am J Neuroradiol |
| Volume | 4 |
| Issue | 3 |
| Pagination | 568-71 |
| Date Published | 01/01/1983 |
| ISSN | 0195-6108 |
| Keywords | Aging, Alzheimer Disease, Dementia, Tomography, Emission-Computed |
| Abstract | In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia. |
| PubMed ID | 6410799 |
| PubMed Central ID | PMC8334899 |