Global cerebrospinal fluid as a zero-reference regularization for brain quantitative susceptibility mapping.
| Publication Type | Academic Article |
| Authors | Dimov A, Nguyen T, Spincemaille P, Sweeney E, Zinger N, Kovanlikaya I, Kopell B, Gauthier S, Wang Y |
| Journal | J Neuroimaging |
| Volume | 32 |
| Issue | 1 |
| Pagination | 141-147 |
| Date Published | 09/04/2021 |
| ISSN | 1552-6569 |
| Keywords | Image Processing, Computer-Assisted, Magnetic Resonance Imaging |
| Abstract | BACKGROUND AND PURPOSE: The objective ofthis study was to demonstrate a global cerebrospinal fluid (CSF) method for a consistent and automated zero referencing of brain quantitative susceptibility mapping (QSM). METHODS: R RESULTS: In scan-rescan experiments, global CSF regularization provided more consistent CSF volume as well as higher repeatability of QSM measurements than ventricular CSF regularization with a smaller bias: -2.7 parts per billion (ppb) versus -0.13 ppb (t-test p<0.05) and a narrower 95% limits of agreement: [-7.25, 6.99] ppb versus [-16.60, 11.19 ppb] (f-test p<0.05). In PD and MS patients, global CSF regularization reduced smoothly varying shadow artifacts and significantly improved the QSM quality score (p<0.001). CONCLUSIONS: The proposed whole brain CSF method for QSM zero referencing improves repeatability and image quality of brain QSM compared to the ventricular CSF method. |
| DOI | 10.1111/jon.12923 |
| PubMed ID | 34480496 |
| PubMed Central ID | PMC8752493 |