Reproducibility of quantitative susceptibility mapping in the brain at two field strengths from two vendors.
| Publication Type | Academic Article |
| Authors | Deh K, Nguyen T, Eskreis-Winkler S, Prince M, Spincemaille P, Gauthier S, Kovanlikaya I, Zhang Y, Wang Y |
| Journal | J Magn Reson Imaging |
| Volume | 42 |
| Issue | 6 |
| Pagination | 1592-600 |
| Date Published | 05/09/2015 |
| ISSN | 1522-2586 |
| Keywords | Brain, Magnetic Resonance Imaging, Multiple Sclerosis |
| Abstract | PURPOSE: To assess the reproducibility of brain quantitative susceptibility mapping (QSM) in healthy subjects and in patients with multiple sclerosis (MS) on 1.5 and 3T scanners from two vendors. MATERIALS AND METHODS: Ten healthy volunteers and 10 patients were scanned twice on a 3T scanner from one vendor. The healthy volunteers were also scanned on a 1.5T scanner from the same vendor and on a 3T scanner from a second vendor. Similar imaging parameters were used for all scans. QSM images were reconstructed using a recently developed nonlinear morphology-enabled dipole inversion (MEDI) algorithm with L1 regularization. Region-of-interest (ROI) measurements were obtained for 20 major brain structures. Reproducibility was evaluated with voxel-wise and ROI-based Bland-Altman plots and linear correlation analysis. RESULTS: ROI-based QSM measurements showed excellent correlation between all repeated scans (correlation coefficient R ≥ 0.97), with a mean difference of less than 1.24 ppb (healthy subjects) and 4.15 ppb (patients), and 95% limits of agreements of within -25.5 to 25.0 ppb (healthy subjects) and -35.8 to 27.6 ppb (patients). Voxel-based QSM measurements had a good correlation (0.64 ≤ R ≤ 0.88) and limits of agreements of -60 to 60 ppb or less. CONCLUSION: Brain QSM measurements have good interscanner and same-scanner reproducibility for healthy and MS subjects, respectively, on the systems evaluated in this study. |
| DOI | 10.1002/jmri.24943 |
| PubMed ID | 25960320 |
| PubMed Central ID | PMC4661140 |