Longitudinal change in TSPO PET imaging in progressive multiple sclerosis.
| Publication Type | Academic Article |
| Authors | Kang Y, Pandya S, Zinger N, Michaelson N, Gauthier S |
| Journal | Ann Clin Transl Neurol |
| Volume | 8 |
| Issue | 8 |
| Pagination | 1755-1759 |
| Date Published | 07/26/2021 |
| ISSN | 2328-9503 |
| Keywords | Gray Matter, Multiple Sclerosis, Chronic Progressive, Receptors, GABA, White Matter |
| Abstract | The objective of this pilot study was to assess a 2-year change in innate immune burden in 15 progressive multiple sclerosis (MS) patients using PK11195-PET. Sixteen age-matched healthy controls (HC) were included for baseline comparison. PK11195 uptake was higher in MS patients compared to HC within normal-appearing white matter (NAWM) and multiple gray matter regions. In patients, PK11195 uptake increased in NAWM (p = 0.01), cortex (p = 0.04), thalamus (p = 0.04), and putamen (p = 0.02) at 12 months. Among patients remaining at 24 months, there was no further increase in PK11195. Our data suggest that innate immune activity may increase over time in patients with progressive MS. |
| DOI | 10.1002/acn3.51431 |
| PubMed ID | 34310086 |
| PubMed Central ID | PMC8351399 |