A digital intervention targeting cognitive control network dysfunction in middle age and older adults with major depression.
| Publication Type | Academic Article |
| Authors | Gunning F, Anguera J, Victoria L, Areán P |
| Journal | Transl Psychiatry |
| Volume | 11 |
| Issue | 1 |
| Pagination | 269 |
| Date Published | 05/04/2021 |
| ISSN | 2158-3188 |
| Keywords | Cognitive Dysfunction, Depressive Disorder, Major |
| Abstract | Nonpharmacological interventions targeting putative network mechanisms of major depressive disorder (MDD) may represent novel treatments. This mechanistic study investigates how a video game-like intervention, designed to improve cognitive control network (CCN) functioning by targeting multitasking, influences the CCN of middle-aged and older adults with MDD. The sample consisted of 34 adults aged 45-75 with SCID-defined diagnosis of MDD, Hamilton depression rating scale scores ≥20, and a deficit in cognitive control. Participants were instructed to play at home for 20-25 min per day, at least 5 times per week, for 4 weeks. Evidence of target engagement was defined a priori as >2/3 of participants showing CCN improvement. CCN engagement was defined as a change in a Z score of ≥0.5 on functional magnetic resonance imaging (fMRI) in activation and functional connectivity of the CCN during task-based and resting-state fMRI, respectively. 74% of participants showed a change in activation of the CCN, and 72% showed an increase in resting-state functional connectivity. Sixty-eight percent demonstrated improved cognitive control function, measured as either improvement on sustained attention or working memory performance or reduced self-reported symptoms of apathy on the frontal systems behavioral scale (FrsBe). Participants also reported a significant reduction in mood symptoms measured by PHQ-9. A remotely deployed neuroscience-informed video game-like intervention improves both CCN functions and mood in middle-aged and older adults with MDD. This easily-disseminated intervention may rescue CCN dysfunction present in a substantial subset of middle-aged and older adults with MDD. |
| DOI | 10.1038/s41398-021-01386-8 |
| PubMed ID | 33947831 |
| PubMed Central ID | PMC8096948 |