Publication Type | Academic Article |
Authors | Mosconi L, Tsui W, Pupi A, De Santi S, Drzezga A, Minoshima S, de Leon M |
Journal | J Nucl Med |
Volume | 48 |
Issue | 7 |
Pagination | 1129-34 |
Date Published | 06/15/2007 |
ISSN | 0161-5505 |
Keywords | Alzheimer Disease, Databases, Factual, Fluorodeoxyglucose F18 |
Abstract | UNLABELLED: The normative reference sample is crucial for the diagnosis of Alzheimer's disease (AD) with automated (18)F-FDG PET analysis. We tested whether an (18)F-FDG PET database of longitudinally confirmed healthy elderly individuals ("normals," or NLs) would improve diagnosis of AD and mild cognitive impairment (MCI). METHODS: Two (18)F-FDG PET databases of 55 NLs with 4-y clinical follow-up examinations were created: one of NLs who remained NL, and the other including a fraction of NLs who declined to MCI at follow-up. Each (18)F-FDG PET scan of 19 NLs, 37 MCI patients, and 33 AD patients was z scored using automated voxel-based comparison to both databases and examined for AD-related abnormalities. RESULTS: Our database of longitudinally confirmed NLs yielded 1.4- to 2-fold higher z scores than did the mixed database in detecting (18)F-FDG PET abnormalities in both the MCI and the AD groups. (18)F-FDG PET diagnosis using the longitudinal NL database identified 100% NLs, 100% MCI patients, and 100% AD patients, which was significantly more accurate for MCI patients than with the mixed database (100% NLs, 68% MCI patients, and 94% AD patients identified). CONCLUSION: Our longitudinally confirmed NL database constitutes reliable (18)F-FDG PET normative values for MCI and AD. |
DOI | 10.2967/jnumed.107.040675 |
PubMed ID | 17574982 |