23Na-NMR study of ion transport across vesicle membranes facilitated by phenylalanine analogs of gramicidin.
| Publication Type | Academic Article |
| Authors | Hinton J, Easton P, Newkirk D, Shungu D |
| Journal | Biochim Biophys Acta |
| Volume | 1146 |
| Issue | 2 |
| Pagination | 191-6 |
| Date Published | 03/14/1993 |
| ISSN | 0006-3002 |
| Keywords | Gramicidin, Phenylalanine, Sodium |
| Abstract | The transport of Na+ ions across phosphatidylcholine/phosphatidylglycerol large unilamellar vesicle membranes facilitated by phenylalanine analogs of gramicidin A has been studied using 23Na-NMR spectroscopy. The four analogs studied were Phe9-, Phe11-, Phe13-and Phe15-gramicidin A. These analogs were found to transport Na+ ions in the following order Phe15 > Phe13 > Phe11 > Phe9. The entropy and enthalpy of activation for the transport of Na+ ions were determined for each analog. A correlation is made between the activation enthalpies and the single channel conductance values of the analogs. |
| DOI | 10.1016/0005-2736(93)90355-4 |
| PubMed ID | 7680900 |