Aβ-related hyperactivation in frontoparietal control regions in cognitively normal elderly.
| Publication Type | Academic Article |
| Authors | Oh H, Steffener J, Razlighi Q, Habeck C, Liu D, Gazes Y, Janicki S, Stern Y |
| Journal | Neurobiol Aging |
| Volume | 36 |
| Issue | 12 |
| Pagination | 3247-3254 |
| Date Published | 08/24/2015 |
| ISSN | 1558-1497 |
| Keywords | Aging, Amyloid beta-Peptides, Cognition, Frontal Lobe, Parietal Lobe |
| Abstract | The accumulation of amyloid-beta (Aβ) peptides, a pathologic hallmark of Alzheimer's disease, has been associated with functional alterations in cognitively normal elderly, most often in the context of episodic memory with a particular emphasis on the medial temporal lobes. The topography of Aβ deposition, however, highly overlaps with frontoparietal control (FPC) regions implicated in cognitive control/working memory. To examine Aβ-related functional alternations in the FPC regions during a working memory task, we imaged 42 young and 57 cognitively normal elderly using functional magnetic resonance imaging during a letter Sternberg task with varying load. Based on (18)F-florbetaben-positron emission tomography scan, we determined older subjects' amyloid positivity (Aβ+) status. Within brain regions commonly recruited by all subject groups during the delay period, age and Aβ deposition were independently associated with load-dependent frontoparietal hyperactivation, whereas additional compensatory Aβ-related hyperactivity was found beyond the FPC regions. The present results suggest that Aβ-related hyperactivation is not specific to the episodic memory system but occurs in the PFC regions as well. |
| DOI | 10.1016/j.neurobiolaging.2015.08.016 |
| PubMed ID | 26382734 |
| PubMed Central ID | PMC4788982 |