Abnormal temporal lobe response in Alzheimer's disease during cognitive processing as measured by 11C-2-deoxy-D-glucose and PET.

Publication Type	Academic Article
Authors	Miller J, de Leon M, Ferris S, Kluger A, George A, Reisberg B, Sachs H, Wolf A
Journal	J Cereb Blood Flow Metab
Volume	7
Issue	2
Pagination	248-51
Date Published	04/01/1987
ISSN	0271-678X
Keywords	Alzheimer Disease, Temporal Lobe, Tomography, Emission-Computed
Abstract	Elderly controls and probable Alzheimer's disease patients underwent serial positron emission tomography (PET) studies during a baseline condition and while performing a verbal memory task. For the temporal lobes, all 7 Alzheimer patients demonstrated a relative shift in glucose metabolic rates to the right hemisphere during the memory condition relative to baseline, and 5 of 7 controls showed a shift to the left hemisphere. Baseline absolute regional metabolic rates replicate previous findings and were somewhat less useful than the memory challenge in differentiating patients from controls. These results indicate that a temporal lobe abnormality in Alzheimer's disease is related to memory performance.
DOI	10.1038/jcbfm.1987.50
PubMed ID	3494029