Abnormalities of cortical thickness in postictal psychosis.

Publication Type	Academic Article
Authors	DuBois J, Devinsky O, Carlson C, Kuzniecky R, Quinn B, Alper K, Butler T, Starner K, Halgren E, Thesen T
Journal	Epilepsy Behav
Volume	21
Issue	2
Pagination	132-6
Date Published	05/04/2011
ISSN	1525-5069
Keywords	Brain Mapping, Cerebral Cortex, Psychotic Disorders, Seizures
Abstract	Postictal psychosis (PIP), the occurrence of psychotic episodes following a seizure, is a common and serious comorbidity in patients with epilepsy. Yet, the anatomical correlates remain poorly defined. Here, we used quantitative MRI morphometry to identify structural abnormalities in the cortex of patients with PIP relative to patients with epilepsy without PIP and age- and gender-matched normal healthy controls. Comparison of patients with epilepsy and PIP with patients with epilepsy without PIP revealed increased cortical thickness in the right lateral prefrontal cortex, right anterior cingulate cortex, and right middle temporal gyrus. The PIP group was distinguished from the EC and NC groups by thicker cortex in the right rostral anterior cingulate cortex and thinner cortex in the right angular gyrus and the left middle temporal region. Findings indicate that PIP is associated with thickening of the right anterior cingulate cortex, which may serve as a marker for patients at risk for developing PIP.
DOI	10.1016/j.yebeh.2011.03.024
PubMed ID	21543262