Age-related changes in brain: I. Magnetic resonance imaging measures of temporal lobe volumes in normal subjects.

Publication Type	Academic Article
Authors	Convit A, de Leon M, Hoptman M, Tarshish C, De Santi S, Rusinek H
Journal	Psychiatr Q
Volume	66
Issue	4
Pagination	343-55
Date Published	01/01/1995
ISSN	0033-2720
Keywords	Aging, Magnetic Resonance Imaging, Temporal Lobe
Abstract	The volume of temporal lobe structures was examined in twenty-seven older (mean age of 69.2 +/- 8.3 years) and ten younger subjects (mean age of 26.1 +/- 4.1 years) using quantitative magnetic resonance imaging (MRI) methods. Multiple regression analysis, using gender, overall atrophy, and head size as covariates, showed unique contributions of age to variance in both medial and lateral temporal lobe volumes. Temporal lobe subregions that showed the strongest unique age-related reductions were the hippocampus, fusiform gyrus, and parahippocampus. These results suggest age-related reductions in temporal lobe subvolumes.
DOI	10.1007/BF02238754
PubMed ID	8584590