Publication Type Academic Article
Authors Marcus D, de Leon M, Goldman J, Logan J, Christman D, Wolf A, Fowler J, Hunter K, Tsai J, Pearson J
Journal Ann Neurol
Volume 26
Issue 1
Pagination 91-4
Date Published 07/01/1989
ISSN 0364-5134
Keywords Alzheimer Disease, Blood Vessels, Deoxy Sugars, Deoxyglucose, Energy Metabolism, Hexokinase, Temporal Lobe
Abstract Microvessels isolated from temporal cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age-matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.
DOI 10.1002/ana.410260114
PubMed ID 2774504
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