Publication Type Academic Article
Authors Hinton J, Newkirk D, Fletcher T, Shungu D
Journal J Magn Reson B
Volume 105
Issue 1
Pagination 11-6
Date Published 09/01/1994
ISSN 1064-1866
Keywords Gramicidin, Lithium, Magnetic Resonance Spectroscopy, Potassium, Receptors, Nicotinic, Sodium
Abstract The magnetization-inversion-transfer NMR technique has been used to determine the activation enthalpy (delta H not equal to) for the transport of the 7Li+, 23Na+, and 39K+ ions through the gramicidin channel incorporated into vesicle membranes. The activation enthalpy obtained for the overall transport of the monovalent cations was found to be in agreement with the selectivity order and single-channel ion conductance values. Furthermore, the magnetization-inversion-transfer technique was also found to be applicable to the channel formed from a synthetic peptide having the same amino acid sequence as the M2 delta transmembrane segment of the nicotinic acetylcholine receptor.
DOI 10.1006/jmrb.1994.1093
PubMed ID 7522868
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