Publication Type Academic Article
Authors Lee J, Dyke J, Ballon D, Ciombor D, Tung G, Aaron R
Journal Orthop Clin North Am
Volume 40
Issue 2
Pagination 249-57
Date Published 04/01/2009
ISSN 1558-1373
Keywords Bone Marrow Diseases, Contrast Media, Edema, Magnetic Resonance Imaging, Osteoarthritis, Hip, Osteoarthritis, Knee, Osteonecrosis
Abstract Osteoarthritis and avascular necrosis are common clinical entities with unknown origins. Recently, vascular changes were implicated in the pathogenesis of both conditions. This article discusses the use of novel noninvasive imaging techniques as a means of assessing bone perfusion and quantifying differences seen in osteoarthritis and avascular necrosis. Review of our human data suggests that the MRI contrast dye is retained for longer periods of time, suggesting decreased perfusion out of regions of osteoarthritis and avascular necrosis. Use of such a noninvasive measure of assessing bone perfusion could be useful in the diagnosis, prevention, and treatment of not only osteoarthritis and avascular necrosis but also other entities that affect the musculoskeletal system.
DOI 10.1016/j.ocl.2008.12.003
PubMed ID 19358910
PubMed Central ID PMC2760337
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