Publication Type Academic Article
Authors Lynch C, Elbau I, Ng T, Wolk D, Zhu S, Ayaz A, Power J, Zebley B, Gunning F, Liston C
Journal Neuron
Volume 110
Issue 20
Pagination 3263-3277.e4
Date Published 09/15/2022
ISSN 1097-4199
Keywords Transcranial Magnetic Stimulation, Brain Mapping
Abstract Transcranial magnetic stimulation (TMS) is used to treat multiple psychiatric and neurological conditions by manipulating activity in particular brain networks and circuits, but individual responses are highly variable. In clinical settings, TMS coil placement is typically based on either group average functional maps or scalp heuristics. Here, we found that this approach can inadvertently target different functional networks in depressed patients due to variability in their functional brain organization. More precise TMS targeting should be feasible by accounting for each patient's unique functional neuroanatomy. To this end, we developed a targeting approach, termed targeted functional network stimulation (TANS). The TANS approach improved stimulation specificity in silico in 8 highly sampled patients with depression and 6 healthy individuals and in vivo when targeting somatomotor functional networks representing the upper and lower limbs. Code for implementing TANS and an example dataset are provided as a resource.
DOI 10.1016/j.neuron.2022.08.012
PubMed ID 36113473
PubMed Central ID PMC11446252
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