β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood-Brain Barrier Opening in Alzheimer's Disease.
| Publication Type | Academic Article |
| Authors | D'Haese P, Ranjan M, Song A, Haut M, Carpenter J, Dieb G, Najib U, Wang P, Mehta R, Chazen J, Hodder S, Claassen D, Kaplitt M, Rezai A |
| Journal | Front Hum Neurosci |
| Volume | 14 |
| Pagination | 593672 |
| Date Published | 10/07/2020 |
| ISSN | 1662-5161 |
| Abstract | The blood-brain barrier (BBB) limits therapeutic delivery in Alzheimer's disease (AD) and other neurological disorders. Animal models have demonstrated safe BBB opening and reduction in β-amyloid plaque with focused ultrasound (FUS). We recently demonstrated the feasibility, safety, and reversibility of FUS-induced BBB opening in the hippocampus and entorhinal cortex in six participants with early AD. We now report the effect of BBB opening with FUS treatment on β-amyloid plaque. Six participants underwent 18F-Florbetaben PET scan at baseline and 1 week after the completion of the third FUS treatment (60 days interval). PET analysis comparing the hippocampus and entorhinal cortex in the treated and untreated hemispheres revealed a decrease in the ratio of 18F-Florbetaben ligand binding. The standard uptake value ratios (SUVr) reduction ranged from 2.7% to 10% with an average of 5.05% (±2.76) suggesting a decrease in β-amyloid plaque. |
| DOI | 10.3389/fnhum.2020.593672 |
| PubMed ID | 33132889 |
| PubMed Central ID | PMC7575813 |