Weill Cornell Medicine
Citigroup Biomedical Imaging Center
Weill Cornell Medicine
Citigroup Biomedical Imaging Center

Brain metabolic differences between sporadic and familial Alzheimer's disease.

Publication Type Academic Article
Authors Mosconi L, Sorbi S, Nacmias B, De Cristofaro M, Fayyaz M, Cellini E, Bagnoli S, Bracco L, Herholz K, Pupi A
Journal Neurology
Volume 61
Issue 8
Pagination 1138-40
Date Published 10/28/2003
ISSN 1526-632X
Keywords Alzheimer Disease, Brain, Glucose
Abstract This FDG-PET study with SPM99 compared 46 patients with sporadic Alzheimer disease (SAD) to 40 patients with familial AD (FAD) and to 35 matched controls. AD groups had equivalent metabolic (METglu) reductions in several cortical and limbic areas with respect to the controls. Patients with FAD showed decreased METglu in the posterior cingulate, parahippocampal, and occipital cortex as compared to the patients with SAD (p < 0.001). Genetic factors lead to phenotypic differences in AD.
DOI 10.1212/01.wnl.0000086816.30011.75
PubMed ID 14581683
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