Publication Type Review
Authors Lewczuk P, Riederer P, O'Bryant S, Verbeek M, Dubois B, Visser P, Jellinger K, Engelborghs S, Ramirez A, Parnetti L, Jack C, Teunissen C, Hampel H, Lleó A, Jessen F, Glodzik L, de Leon M, Fagan A, Molinuevo J, Jansen W, Winblad B, Shaw L, Andreasson U, Otto M, Mollenhauer B, Wiltfang J, Turner M, Zerr I, Handels R, Thompson A, Johansson G, Ermann N, Trojanowski J, Karaca I, Wagner H, Oeckl P, van Waalwijk van Doorn L, Bjerke M, Kapogiannis D, Kuiperij H, Farotti L, Li Y, Gordon B, Epelbaum S, Vos S, Klijn C, Van Nostrand W, Minguillon C, Schmitz M, Gallo C, Lopez Mato A, Thibaut F, Lista S, Alcolea D, Zetterberg H, Blennow K, Kornhuber J
Journal World J Biol Psychiatry
Volume 19
Issue 4
Pagination 244-328
Date Published 10/27/2017
ISSN 1814-1412
Keywords Biological Psychiatry, Biomarkers, Consensus, Dementia, Neurodegenerative Diseases, Societies, Medical
Abstract In the 12 years since the publication of the first Consensus Paper of the WFSBP on biomarkers of neurodegenerative dementias, enormous advancement has taken place in the field, and the Task Force takes now the opportunity to extend and update the original paper. New concepts of Alzheimer's disease (AD) and the conceptual interactions between AD and dementia due to AD were developed, resulting in two sets for diagnostic/research criteria. Procedures for pre-analytical sample handling, biobanking, analyses and post-analytical interpretation of the results were intensively studied and optimised. A global quality control project was introduced to evaluate and monitor the inter-centre variability in measurements with the goal of harmonisation of results. Contexts of use and how to approach candidate biomarkers in biological specimens other than cerebrospinal fluid (CSF), e.g. blood, were precisely defined. Important development was achieved in neuroimaging techniques, including studies comparing amyloid-β positron emission tomography results to fluid-based modalities. Similarly, development in research laboratory technologies, such as ultra-sensitive methods, raises our hopes to further improve analytical and diagnostic accuracy of classic and novel candidate biomarkers. Synergistically, advancement in clinical trials of anti-dementia therapies energises and motivates the efforts to find and optimise the most reliable early diagnostic modalities. Finally, the first studies were published addressing the potential of cost-effectiveness of the biomarkers-based diagnosis of neurodegenerative disorders.
DOI 10.1080/15622975.2017.1375556
PubMed ID 29076399
PubMed Central ID PMC5916324
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