Publication Type Academic Article
Authors Tozlu C, Ozenne B, Cho T, Nighoghossian N, Mikkelsen I, Derex L, Hermier M, Pedraza S, Fiehler J, Østergaard L, Berthezène Y, Baron J, Maucort-Boulch D
Journal Eur J Neurosci
Volume 50
Issue 10
Pagination 3590-3598
Date Published 09/12/2019
ISSN 1460-9568
Keywords Algorithms, Brain, Brain Ischemia, Magnetic Resonance Imaging, Stroke
Abstract In acute ischaemic stroke, identifying brain tissue at high risk of infarction is important for clinical decision-making. This tissue may be identified with suitable classification methods from magnetic resonance imaging data. The aim of the present study was to assess and compare the performance of five popular classification methods (adaptive boosting, logistic regression, artificial neural networks, random forest and support vector machine) in identifying tissue at high risk of infarction on human voxel-based brain imaging data. The classification methods were used with eight MRI parameters, including diffusion-weighted imaging and perfusion-weighted imaging obtained in 55 patients. The five criteria used to assess the performance of the methods were the area under the receiver operating curve (AUCroc ), the area under the precision-recall curve (AUCpr ), sensitivity, specificity and the Dice coefficient. The methods performed equally in terms of sensitivity and specificity, while the results of AUCroc and the Dice coefficient were significantly better for adaptive boosting, logistic regression, artificial neural networks and random forest. However, there was no statistically significant difference between the performances of these five classification methods regarding AUCpr , which was the main comparison metric. Machine learning methods can provide valuable prognostic information using multimodal imaging data in acute ischaemic stroke, which in turn can assist in developing personalized treatment decision for clinicians after a thorough validation of methods with an independent data set.
DOI 10.1111/ejn.14507
PubMed ID 31278787
Back to Top