Comparison of contrast enhancement and diffusion-weighted magnetic resonance imaging in healthy and cancerous breast tissue.

Publication Type	Academic Article
Authors	Cho G, Moy L, Kim S, Klautau Leite A, Baete S, Babb J, Sodickson D, Sigmund E
Journal	Eur J Radiol
Volume	84
Issue	10
Pagination	1888-93
Date Published	07/02/2015
ISSN	1872-7727
Keywords	Breast, Breast Neoplasms, Contrast Media, Diffusion Magnetic Resonance Imaging, Image Enhancement, Magnetic Resonance Imaging
Abstract	OBJECTIVE: To measure background parenchymal enhancement (BPE) and compare with other contrast enhancement values and diffusion-weighted MRI parameters in healthy and cancerous breast tissue at the clinical level. MATERIALS AND METHODS: This HIPAA-compliant, IRB approved retrospective study enrolled 77 patients (38 patients with breast cancer - mean age 51.8 ± 10.0 years; 39 high-risk patients for screening evaluation - mean age 46.3 ± 11.7 years), who underwent contrast-enhanced 3T breast MRI. Contrast enhanced MRI and diffusion-weighted imaging were performed to quantify BPE, lesion contrast enhancement, and apparent diffusion coefficient (ADC) metrics in fibroglandular tissue (FGT) and lesions. RESULTS: BPE did not correlate with ADC values. Mean BPE for the lesion-bearing patients was higher (43.9%) compared to that of the high-risk screening patients (28.3%, p=0.004). Significant correlation (r=0.37, p<0.05) was found between BPE and lesion contrast enhancement. CONCLUSION: No significant association was observed between parenchymal or lesion enhancement with conventional apparent diffusion metrics, suggesting that proliferative processes are not co-regulated in cancerous and parenchymal tissue.
DOI	10.1016/j.ejrad.2015.06.023
PubMed ID	26220915