Comparison of contrast enhancement and diffusion-weighted magnetic resonance imaging in healthy and cancerous breast tissue.
| Publication Type | Academic Article |
| Authors | Cho G, Moy L, Kim S, Klautau Leite A, Baete S, Babb J, Sodickson D, Sigmund E |
| Journal | Eur J Radiol |
| Volume | 84 |
| Issue | 10 |
| Pagination | 1888-93 |
| Date Published | 07/02/2015 |
| ISSN | 1872-7727 |
| Keywords | Breast, Breast Neoplasms, Contrast Media, Diffusion Magnetic Resonance Imaging, Image Enhancement, Magnetic Resonance Imaging |
| Abstract | OBJECTIVE: To measure background parenchymal enhancement (BPE) and compare with other contrast enhancement values and diffusion-weighted MRI parameters in healthy and cancerous breast tissue at the clinical level. MATERIALS AND METHODS: This HIPAA-compliant, IRB approved retrospective study enrolled 77 patients (38 patients with breast cancer - mean age 51.8 ± 10.0 years; 39 high-risk patients for screening evaluation - mean age 46.3 ± 11.7 years), who underwent contrast-enhanced 3T breast MRI. Contrast enhanced MRI and diffusion-weighted imaging were performed to quantify BPE, lesion contrast enhancement, and apparent diffusion coefficient (ADC) metrics in fibroglandular tissue (FGT) and lesions. RESULTS: BPE did not correlate with ADC values. Mean BPE for the lesion-bearing patients was higher (43.9%) compared to that of the high-risk screening patients (28.3%, p=0.004). Significant correlation (r=0.37, p<0.05) was found between BPE and lesion contrast enhancement. CONCLUSION: No significant association was observed between parenchymal or lesion enhancement with conventional apparent diffusion metrics, suggesting that proliferative processes are not co-regulated in cancerous and parenchymal tissue. |
| DOI | 10.1016/j.ejrad.2015.06.023 |
| PubMed ID | 26220915 |