Publication Type Academic Article
Authors Ni W, Christen T, Zun Z, Zaharchuk G
Journal Magn Reson Med
Volume 73
Issue 3
Pagination 1228-36
Date Published 04/18/2014
ISSN 1522-2594
Keywords Algorithms, Brain, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging
Abstract PURPOSE: R2', the reversible component of transverse relaxation, is an important susceptibility measurement for studies of brain physiology and pathologies. In existing literature, different R2' measurement methods are used with assumption of equivalency. This study explores the choice of measurement method in healthy, young subjects at 3T. METHODS: In this study, a modified gradient-echo sampling of free induction decay and echo (GESFIDE) sequence was used to compare four standard R2' measurement methods: asymmetric spin echo (ASE), standard GESFIDE, gradient echo sampling of the spin echo (GESSE), and separate R2 and R2* mapping. RESULTS: GESSE returned lower R2' measurements than other methods (P < 0.05). Intersubject mean R2' in gray matter was found to be 2.7 s(-1) using standard GESFIDE and GESSE, versus 3.4-3.8 s(-1) using other methods. In white matter, mean R2' from GESSE was 2.3 s(-1) while other methods produced 3.7-4.3 s(-1) . R2 correction was applied to partially reduce the discrepancies between the methods, but significant differences remained, likely due to violation of the fundamental assumption of a single-compartmental tissue model, and hence monoexponential decay. CONCLUSION: R2' measurements are influenced significantly by the choice of method. Awareness of this issue is important when designing and interpreting studies that involve R2' measurements.
DOI 10.1002/mrm.25232
PubMed ID 24753286
PubMed Central ID PMC4308575
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