Publication Type Academic Article
Authors Kale S, Burga R, Sweeney E, Zun Z, Sze R, Tuesca A, Subramony J, Fernandes R
Journal Int J Nanomedicine
Volume 12
Pagination 6413-6424
Date Published 09/05/2017
ISSN 1178-2013
Keywords Contrast Media, Ferrocyanides, Magnetic Resonance Imaging, Nanoparticles, Phototherapy
Abstract Theranostic nanoparticles offer the potential for mixing and matching disparate diagnostic and therapeutic functionalities within a single nanoparticle for the personalized treatment of diseases. In this article, we present composite iron oxide-gadolinium-containing Prussian blue nanoparticles (Fe3O4@GdPB) as a novel theranostic agent for T1-weighted magnetic resonance imaging (MRI) and photothermal therapy (PTT) of tumors. These particles combine the well-described properties and safety profiles of the constituent Fe3O4 nanoparticles and gadolinium-containing Prussian blue nanoparticles. The Fe3O4@GdPB nanoparticles function both as effective MRI contrast agents and PTT agents as determined by characterizing studies performed in vitro and retain their properties in the presence of cells. Importantly, the Fe3O4@GdPB nanoparticles function as effective MRI contrast agents in vivo by increasing signal:noise ratios in T1-weighted scans of tumors and as effective PTT agents in vivo by decreasing tumor growth rates and increasing survival in an animal model of neuroblastoma. These findings demonstrate the potential of the Fe3O4@GdPB nanoparticles to function as effective theranostic agents.
DOI 10.2147/IJN.S144515
PubMed ID 28919744
PubMed Central ID PMC5592912
Back to Top