Publication Type	Academic Article
Authors	Wolf O, Convit A, McHugh P, Kandil E, Thorn E, De Santi S, McEwen B, de Leon M
Journal	Behav Neurosci
Volume	115
Issue	5
Pagination	1002-11
Date Published	10/01/2001
ISSN	0735-7044
Keywords	Hydrocortisone, Mental Recall, Verbal Learning
Abstract	Nine young and 11 elderly men participated in this placebo-controlled, double-blind, crossover study (0.5 mg/kg cortisol or intravenous placebo). Participants learned a word list before cortisol administration, and delayed recall was then tested. A 2nd word list was learned and recalled after drug administration. In addition, the Paragraph Recall Test and tests measuring working memory (Digit Span), attention (timed cancellation), and response inhibition (Stroop Color and Word Test) were administered at 2 time points after drug administration. Cortisol reduced recall from the word list learned before treatment in both groups but did not influence recall of the list learned after treatment. In contrast, Digit Span performance was decreased by cortisol in young but not elderly participants. The possibility that differential age-associated brain changes might underlie the present results is discussed.
DOI	10.1037//0735-7044.115.5.1002
PubMed ID	11584913