[Depression and addiction comorbidity: towards a common molecular target?].

Publication Type	Review
Authors	Arango-Lievano M, Kaplitt M
Journal	Med Sci (Paris)
Volume	31
Issue	5
Pagination	546-50
Date Published	06/09/2015
ISSN	0767-0974
Keywords	Annexin A2, Depression, Depressive Disorder, Nerve Tissue Proteins, Nucleus Accumbens, S100 Proteins, Substance-Related Disorders
Abstract	The comorbidity of depression and cocaine addiction suggests shared mechanisms and anatomical pathways. Specifically, the limbic structures, such as the nucleus accumbens (NAc), play a crucial role in both disorders. P11 (S100A10) is a promising target for manipulating depression and addiction in mice. We summarized the recent genetic and viral strategies used to determine how the titration of p11 levels within the NAc affects hedonic behavior and cocaine reward learning in mice. In particular, p11 in the ChAT+ cells or DRD1+ MSN of the NAc, controls depressive-like behavior or cocaine reward, respectively. Treatments to counter maladaptation of p11 levels in the NAc could provide novel therapeutic opportunities for depression and cocaine addiction in humans.
DOI	10.1051/medsci/20153105017
PubMed ID	26059306