Publication Type Academic Article
Authors Ozsahin I, Zhou L, Wang X, Garetti J, Jamison K, Xi K, Tanzi E, Jaywant A, Patchell A, Maloney T, de Leon M, Kuceyeski A, Shah S, Li Y, Butler T
Journal J Alzheimers Dis Rep
Volume 8
Issue 1
Pagination 355-361
Date Published 02/20/2024
ISSN 2542-4823
Abstract Diffusion tensor imaging along perivascular spaces (DTI-ALPS) is a novel MRI method for assessing brain interstitial fluid dynamics, potentially indexing glymphatic function. Failed glymphatic clearance is implicated in Alzheimer's disease (AD) pathophysiology. We assessed the contribution of age and female sex (strong AD risk factors) to DTI-ALPS index in healthy subjects. We also for the first time assessed the effect of head size. In accord with prior studies, we show reduced DTI-ALPS index with aging, and in men compared to women. However, head size may be a major contributing factor to this counterintuitive sex difference.
DOI 10.3233/ADR-230143
PubMed ID 38405348
PubMed Central ID PMC10894616
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