Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury.
| Publication Type | Academic Article |
| Authors | Bardin J, Fins J, Katz D, Hersh J, Heier L, Tabelow K, Dyke J, Ballon D, Schiff N, Voss H |
| Journal | Brain |
| Volume | 134 |
| Issue | Pt 3 |
| Pagination | 769-82 |
| Date Published | 03/01/2011 |
| ISSN | 1460-2156 |
| Keywords | Brain, Brain Injuries, Cognition Disorders, Magnetic Resonance Imaging |
| Abstract | Functional neuroimaging methods hold promise for the identification of cognitive function and communication capacity in some severely brain-injured patients who may not retain sufficient motor function to demonstrate their abilities. We studied seven severely brain-injured patients and a control group of 14 subjects using a novel hierarchical functional magnetic resonance imaging assessment utilizing mental imagery responses. Whereas the control group showed consistent and accurate (for communication) blood-oxygen-level-dependent responses without exception, the brain-injured subjects showed a wide variation in the correlation of blood-oxygen-level-dependent responses and overt behavioural responses. Specifically, the brain-injured subjects dissociated bedside and functional magnetic resonance imaging-based command following and communication capabilities. These observations reveal significant challenges in developing validated functional magnetic resonance imaging-based methods for clinical use and raise interesting questions about underlying brain function assayed using these methods in brain-injured subjects. |
| DOI | 10.1093/brain/awr005 |
| PubMed ID | 21354974 |
| PubMed Central ID | PMC3044833 |