Publication Type	Academic Article
Authors	Ivanidze J, Mackay M, Hoang A, Chi J, Cheng K, Aranow C, Volpe B, Diamond B, Sanelli P
Journal	AJNR Am J Neuroradiol
Volume	40
Issue	3
Pagination	408-411
Date Published	02/07/2019
ISSN	1936-959X
Keywords	Blood-Brain Barrier, Hippocampus, Magnetic Resonance Imaging, Neuroimaging
Abstract	We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.
DOI	10.3174/ajnr.A5962
PubMed ID	30733256
PubMed Central ID	PMC7028673