Publication Type Academic Article
Authors Razlighi Q, Oh H, Habeck C, O'Shea D, Gazes E, Eich T, Parker D, Lee S, Stern Y
Journal Cereb Cortex
Volume 27
Issue 7
Pagination 3586-3599
Date Published 07/01/2017
ISSN 1460-2199
Keywords Aging, Brain, Brain Mapping, Cognition
Abstract Although the brain/behavior correlation is one of the premises of cognitive neuroscience, there is still no consensus about the relationship between brain measures and cognitive function, and only little is known about the effect of age on this relationship. We investigated the age-associated variations on the spatial patterns of cortical thickness correlates of four cognitive domains. We showed that the spatial distribution of the cortical thickness correlates of each cognitive domain is distinctive and depicts varying age-association differences across the adult lifespan. Specifically, the present study provides evidence that distinct cognitive domains are associated with unique structural patterns in three adulthood periods: Early, middle, and late adulthood. These findings suggest a dynamic interaction between multiple neural substrates supporting each cognitive domain across the adult lifespan.
DOI 10.1093/cercor/bhw179
PubMed ID 27436131
PubMed Central ID PMC6059207
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