Dynamic Patterns of Brain Structure-Behavior Correlation Across the Lifespan.

Publication Type	Academic Article
Authors	Razlighi Q, Oh H, Habeck C, O'Shea D, Gazes E, Eich T, Parker D, Lee S, Stern Y
Journal	Cereb Cortex
Volume	27
Issue	7
Pagination	3586-3599
Date Published	07/01/2017
ISSN	1460-2199
Keywords	Aging, Brain, Brain Mapping, Cognition
Abstract	Although the brain/behavior correlation is one of the premises of cognitive neuroscience, there is still no consensus about the relationship between brain measures and cognitive function, and only little is known about the effect of age on this relationship. We investigated the age-associated variations on the spatial patterns of cortical thickness correlates of four cognitive domains. We showed that the spatial distribution of the cortical thickness correlates of each cognitive domain is distinctive and depicts varying age-association differences across the adult lifespan. Specifically, the present study provides evidence that distinct cognitive domains are associated with unique structural patterns in three adulthood periods: Early, middle, and late adulthood. These findings suggest a dynamic interaction between multiple neural substrates supporting each cognitive domain across the adult lifespan.
DOI	10.1093/cercor/bhw179
PubMed ID	27436131
PubMed Central ID	PMC6059207