Effects of memantine on cerebrospinal fluid biomarkers of neurofibrillary pathology.
| Publication Type | Academic Article |
| Authors | Glodzik L, De Santi S, Rich K, Brys M, Pirraglia E, Mistur R, Switalski R, Mosconi L, Sadowski M, Zetterberg H, Blennow K, de Leon M |
| Journal | J Alzheimers Dis |
| Volume | 18 |
| Issue | 3 |
| Pagination | 509-13 |
| Date Published | 01/01/2009 |
| ISSN | 1875-8908 |
| Keywords | Alzheimer Disease, Antiparkinson Agents, Brain, Memantine, Neurofibrillary Tangles |
| Abstract | Previous studies showed that memantine inhibits tau hyperphosphorylation in vitro. In this study, phosphorylated tau (P-tau) and total tau (T-tau) were measured before and after 6 month treatment with memantine in 12 subjects ranging from normal cognition with subjective memory complaints, through mild cognitive impairment to mild Alzheimer's disease. Thirteen non-treated individuals served as controls. Treatment was associated with a reduction of P-tau in subjects with normal cognition. No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group. |
| DOI | 10.3233/JAD-2009-1183 |
| PubMed ID | 19661628 |
| PubMed Central ID | PMC3123136 |