Publication Type Academic Article
Authors Glodzik L, De Santi S, Rich K, Brys M, Pirraglia E, Mistur R, Switalski R, Mosconi L, Sadowski M, Zetterberg H, Blennow K, de Leon M
Journal J Alzheimers Dis
Volume 18
Issue 3
Pagination 509-13
Date Published 01/01/2009
ISSN 1875-8908
Keywords Alzheimer Disease, Antiparkinson Agents, Brain, Memantine, Neurofibrillary Tangles
Abstract Previous studies showed that memantine inhibits tau hyperphosphorylation in vitro. In this study, phosphorylated tau (P-tau) and total tau (T-tau) were measured before and after 6 month treatment with memantine in 12 subjects ranging from normal cognition with subjective memory complaints, through mild cognitive impairment to mild Alzheimer's disease. Thirteen non-treated individuals served as controls. Treatment was associated with a reduction of P-tau in subjects with normal cognition. No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group.
DOI 10.3233/JAD-2009-1183
PubMed ID 19661628
PubMed Central ID PMC3123136
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