Publication Type Review
Authors Lantrip C, Gunning F, Flashman L, Roth R, Holtzheimer P
Journal J ECT
Volume 33
Issue 2
Pagination 73-80
Date Published 06/01/2017
ISSN 1533-4112
Keywords Cognition, Depressive Disorder, Major, Emotions, Transcranial Magnetic Stimulation
Abstract Depression negatively impacts quality of life and is associated with high mortality rates. Recent research has demonstrated that improvement in depression symptoms with transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) may involve changes in the cognitive control network, a regulatory system modulating the function of cognitive and emotional systems, composed of the DLPFC, dorsal anterior cingulate, and posterior parietal cortices. Transcranial magnetic stimulation to the DLPFC node of the cognitive control network may have antidepressant efficacy via direct effects on cognitive control processes involved in emotion regulation. This review provides a review of the impact of TMS on cognitive control processes, especially those related to emotion regulation, and posits that these effects are critical to the mechanism of action of TMS for depression. Treatment implications and future directions for study are discussed.
DOI 10.1097/YCT.0000000000000386
PubMed ID 28072659
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